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BACKGROUND
Although sexual dysfunction is common after hematopoietic stem cell transplantation (HCT), interventions to address sexual function are lacking.
METHODS
We conducted a pilot study to assess the feasibility and preliminary efficacy of a multimodal intervention to address sexual dysfunction in allogeneic HCT survivors. Transplant clinicians screened HCT survivors ≥3 months post‐HCT for...
BACKGROUND
Hypertension (HTN) is an established class effect of vascular endothelial growth factor receptor (VEGFR) inhibition. In the phase 3 Study of (E7080) Lenvatinib in Differentiated Cancer of the Thyroid (SELECT) trial, HTN was the most frequent adverse event of lenvatinib, an inhibitor of VEGFR1, VEGFR2, VEGFR3, fibroblast growth factor receptor 1 (FGFR1), FGFR2, FGFR3, FGFR4, platelet‐derived...
BACKGROUND
Reirradiation for locoregionally recurrent nasopharyngeal carcinoma (NPC) after a definitive dose of radiotherapy (RT) is challenging and usually associated with severe toxicities. Intensity‐modulated carbon ion RT (IMCT) offers physical/biologic advantages over photon‐based intensity‐modulated RT. Herein, the authors report their initial experience of IMCT in previously irradiated patients...
Chemotherapy‐induced peripheral neuropathy (CIPN) is a serious adverse side effect of many chemotherapeutic agents, affecting >60% of patients with cancer. Moreover, CIPN persists long into survivorship in approximately 20% to 30% of these patients. To the authors' knowledge, no drugs have been approved to date by the US Food and Drug Administration to effectively manage chemotherapy‐induced neuropathic...
BACKGROUND
Two or more different epidermal growth factor receptor (EGFR) mutations can be detected within a single tumor sample, which represents complex mutations. However, the frequency and efficacy of tyrosine kinase inhibitor (TKI) treatments for patients harboring these mutations are unknown.
METHODS
From January 2011 to January 2017, patients diagnosed with EGFR mutations were screened. The...
BACKGROUND
The objective of the current study was to characterize and identify factors associated with perceptions of risk of infertility among adult male survivors of childhood cancer.
METHODS
A total of 1233 adult male survivors from the Childhood Cancer Survivor Study who were without a history of disease recurrence or subsequent malignancy reported their perceptions of their risk of infertility...
BACKGROUND
Risk stratification of newly diagnosed patients with mantle cell lymphoma (MCL) primarily is based on the MCL International Prognostic Index (MIPI) and Ki‐67 proliferative index. Single‐center studies have reported inferior outcomes in patients with a complex karyotype (CK), but this remains an area of controversy.
METHODS
The authors retrospectively reviewed 483 patients from 5 academic...
BACKGROUND
The authors investigated disparities in the survivorship experience among Latinas with breast cancer (BC) in comparison with non‐Latinas.
METHODS
A cross‐sectional bilingual telephone survey was conducted among 212 Latina and non‐Latina women within 10 to 24 months after a diagnosis of BC (AJCC TNM staging system stage 0‐III) at 2 Los Angeles County public hospitals. Data were collected...
BACKGROUND
Given the adverse consequences of psychiatric and psychosocial morbidity on the quality of life for patients with cancer, prompt detection of psychological symptoms is mandatory. The authors examined the properties and accuracy of the Brief Symptom Inventory (the 53‐item version [BSI] and the 18‐item version [BSI‐18]) for the detection of psychiatric morbidity compared with the World Health...
BACKGROUND
Posttransplant lymphoproliferative disorder (PTLD) is a life‐threatening complication of solid organ transplantation. Histologic heterogeneity and a lack of treatment standards have made evaluating clinical outcomes in specific patient populations difficult. This systematic literature review investigated the impact of the PTLD histologic subtype on survival in a large data set.
METHODS...
BACKGROUND
This is the first report of long‐term (>10 years) safety, tolerability, and survival data on patients with non–small cell lung cancer (NSCLC) who received treatment with gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor.
METHODS
Patients with advanced NSCLC (N = 191) who entered the IRESSA Clinical Access Program (ICAP) (June 2011 to January 2013) and...
BACKGROUND
This study compared the efficacy and safety of treatment with erlotinib plus pazopanib versus erlotinib plus placebo in patients with previously treated advanced non–small cell lung cancer (NSCLC).
METHODS
Patients with progressive‐stage IV NSCLC after either 1 or 2 previous chemotherapy regimens were randomized to receive erlotinib (150 mg by mouth daily) with either pazopanib (600...
BACKGROUND
False‐positive cancer screening results may affect a patient's willingness to obtain future screening.
METHODS
The authors conducted logistic regression analysis of 450,484 person‐years of electronic medical records (2006‐2015) in 92,405 individuals aged 50 to 75 years. Exposures were false‐positive breast, prostate, or colorectal cancer screening test results (repeat breast imaging...
BACKGROUND
For patients who have acute promyelocytic leukemia (APL) in second complete remission (CR2), optimal postremission strategies remain undefined.
METHODS
The role of an oral arsenic trioxide (As2O3)‐based regimen in the management of patients who had APL in CR2 was examined.
RESULTS
Seventy‐three patients with APL in first relapse (R1) were studied. Oral As2O3‐based reinduction resulted...
Although many of the 16,000 children in the United States diagnosed who are with cancer each year could benefit from pediatric palliative care, these services remain underused. Evidence regarding the barriers impeding access to comprehensive palliative care is dispersed in the literature, and evidence specific to pediatric oncology remains particularly sparse. The purpose of the current review was...
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